Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 346 (6286), 719-23

Stimulation of p21ras Upon T-cell Activation

Affiliations

Stimulation of p21ras Upon T-cell Activation

J Downward et al. Nature.

Abstract

External signals that control the activity of proteins encoded by the ras proto-oncogenes have not previously been characterized. It is now shown that stimulation of the antigen receptor of T lymphocytes causes a rapid activation of p21ras. The mechanism seems to involve a decrease in the activity of GAP, the GTPase-activating protein, on stimulation of protein kinase C. In lymphocytes, p21ras may therefore be an important mediator of the action of protein kinase C.

Comment in

Similar articles

See all similar articles

Cited by 207 PubMed Central articles

See all "Cited by" articles

LinkOut - more resources

Feedback