Stimulation of p21ras upon T-cell activation

Nature. 1990 Aug 23;346(6286):719-23. doi: 10.1038/346719a0.


External signals that control the activity of proteins encoded by the ras proto-oncogenes have not previously been characterized. It is now shown that stimulation of the antigen receptor of T lymphocytes causes a rapid activation of p21ras. The mechanism seems to involve a decrease in the activity of GAP, the GTPase-activating protein, on stimulation of protein kinase C. In lymphocytes, p21ras may therefore be an important mediator of the action of protein kinase C.

MeSH terms

  • GTPase-Activating Proteins
  • Genes, ras*
  • Humans
  • In Vitro Techniques
  • Kinetics
  • Lymphocyte Activation
  • Oncogene Protein p21(ras) / genetics*
  • Oncogene Protein p21(ras) / metabolism
  • Protein Kinase C / metabolism
  • Proteins / metabolism*
  • Receptors, Antigen, T-Cell / immunology
  • Signal Transduction
  • T-Lymphocytes / enzymology
  • T-Lymphocytes / immunology*
  • ras GTPase-Activating Proteins


  • GTPase-Activating Proteins
  • Proteins
  • Receptors, Antigen, T-Cell
  • ras GTPase-Activating Proteins
  • Protein Kinase C
  • Oncogene Protein p21(ras)