IL-17 producing cells in host defense and atopy

Curr Opin Immunol. 2011 Dec;23(6):784-8. doi: 10.1016/j.coi.2011.09.006. Epub 2011 Oct 21.


The roles of IL-17 producing cells have been the subject of significant research in the fields of autoimmunity, host defense, and recently, atopy. A substantial number of genetic disease with disruptions in the IL-17 pathway have been identified and characterized in past few years, not only enhancing our understanding, but also raising new and complex questions. The connection between IL-17 and atopic disease, in particular, is complex, but it merits further study which may ultimately lead to therapies targeting the Th17 pathway in infectious and/or allergic settings.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Anaphylaxis / immunology
  • Animals
  • Asthma / immunology
  • Basophils / cytology
  • Basophils / immunology
  • Dermatitis, Atopic / immunology*
  • Humans
  • Interleukin-17 / biosynthesis
  • Interleukin-17 / immunology*


  • Interleukin-17