Blocking the postpartum mouse dam's CB1 receptors impairs maternal behavior as well as offspring development and their adult social-emotional behavior

Behav Brain Res. 2012 Jan 15;226(2):481-92. doi: 10.1016/j.bbr.2011.10.016. Epub 2011 Oct 15.


Maternal care is the newborns' first experience of social interaction, which affects their development and social competence throughout life. For the first time, we investigated the involvement of the endocannabinoid system (ECS) in mother-infant interaction in mice. We found that blocking the dam's CB1 receptors (CB1R) by the antagonist/inverse agonist rimonabant (SR141716) during postpartum days 1-8 affected maternal behavior as well as the social and emotional characteristics of the offspring as adults. Pups of rimonabant treated dams (RTD) had lower body weight during the first week of life and emitted fewer ultrasonic vocalizations (USVs) than vehicle treated dams (VTD). RTD crouched less over their pups and exhibited delayed pup retrieval. In Y-maze preference tests conducted at weaning age, females and males of both groups preferred their dam over milk. Males and females of RTD preferred dam over pup and pup over milk as opposed to the control group. At the age of 2.5 months, males of RTD displayed less motor activity. In the social behavior test, RTD male and female offspring were both more active, showing higher levels of active social interaction and rearing. These results indicate that the ECS is crucial for establishment of maternal behavior during the first postpartum week, with a long-term impact on the offspring's socio-emotional development.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn / growth & development*
  • Animals, Newborn / physiology
  • Animals, Outbred Strains
  • Behavior, Animal / drug effects
  • Behavior, Animal / physiology*
  • Body Temperature / drug effects
  • Body Temperature / physiology
  • Body Weight / drug effects
  • Emotions / drug effects
  • Emotions / physiology
  • Female
  • Male
  • Maternal Behavior / drug effects
  • Maternal Behavior / psychology*
  • Maze Learning / drug effects
  • Maze Learning / physiology
  • Mice
  • Piperidines / pharmacology*
  • Postpartum Period / drug effects*
  • Pyrazoles / pharmacology*
  • Receptor, Cannabinoid, CB1 / antagonists & inhibitors*
  • Receptor, Cannabinoid, CB1 / physiology*
  • Rimonabant
  • Social Behavior
  • Vocalization, Animal / drug effects
  • Vocalization, Animal / physiology


  • Piperidines
  • Pyrazoles
  • Receptor, Cannabinoid, CB1
  • Rimonabant