Nucleoid occlusion and bacterial cell division

Nat Rev Microbiol. 2011 Oct 24;10(1):8-12. doi: 10.1038/nrmicro2671.


The bacterial cell cycle requires the tight regulation and precise coordination of several sophisticated cellular processes. Prominent among them is the formation of the dividing wall or septum, which has to take place at the right time and place to ensure equality of the progeny and integrity of the genome. Nucleoid occlusion is a defence mechanism that prevents the chromosome from being bisected and broken by the division septum. It does so by preventing Z ring formation near the nucleoid, which also helps to determine the location of septation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacillus subtilis / cytology*
  • Bacillus subtilis / growth & development*
  • Bacterial Proteins / metabolism
  • Carrier Proteins / metabolism
  • Cell Cycle Proteins / metabolism
  • Cell Division*
  • DNA Replication
  • Escherichia coli / cytology*
  • Escherichia coli / growth & development*
  • Escherichia coli Proteins / metabolism
  • Models, Biological


  • Bacterial Proteins
  • Carrier Proteins
  • Cell Cycle Proteins
  • Escherichia coli Proteins
  • SlmA protein, E coli