Inherited predisposition to cancer

Trends Genet. 1990 Jul;6(7):213-8. doi: 10.1016/0168-9525(90)90181-5.


In a minority of cancers, the family history, and sometimes characteristic abnormalities in growth or development of target tissues, suggests strong inherited predisposition. There may also be a much larger number of cases who are less strongly predisposed, with important implications for screening and prevention; because there is usually no family history, however, the recognition and investigation of these cases poses a major problem.

Publication types

  • Review

MeSH terms

  • Female
  • Gene Frequency
  • Humans
  • Male
  • Neoplasms / genetics*
  • Neoplastic Syndromes, Hereditary / genetics*
  • Pedigree