Radiation recall myositis in pediatric Ewing sarcoma

Pediatr Blood Cancer. 2012 Sep;59(3):570-2. doi: 10.1002/pbc.23374. Epub 2011 Oct 20.


Radiation recall is a rare and poorly understood phenomenon, characterized by an acute inflammatory reaction within the previously irradiated area, triggered by a precipitating systemic agent. This reaction typically affects the skin, and radiation recall myositis in the absence of cutaneous involvement has rarely been described in the literature. In this report, we present two cases of radiation recall in pediatric Ewing sarcoma patients receiving successive proton radiotherapy and chemotherapy, with magnetic resonance imaging (MRI) of muscle edema within the prior radiation fields.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Child
  • Combined Modality Therapy
  • Female
  • Humans
  • Male
  • Myositis / etiology*
  • Proton Therapy*
  • Radiotherapy / adverse effects*
  • Radiotherapy, Adjuvant
  • Sarcoma, Ewing / drug therapy
  • Sarcoma, Ewing / radiotherapy*


  • Protons