Tumoral calcinosis (TC) is a rare problem that can be idiopathic (primary) or secondary to other diseases, particularly end-stage renal disease. Although these 2 types of TC do not differ in their radiologic and histopathologic presentations, their treatment modalities may be changed on the basis of etiology. Surgical resection of the calcified mass is the main treatment for the primary type, but should be avoided in hemodialysis-related types, which are instead often treated with parathyroidectomy. In this article, we report on 2 cases of TC (different types). We also describe several aspects of diagnosis and different therapeutic approaches through a review of the literature.