Biomarkers in Type 2 diabetes: improving risk stratification with the PreDx ® Diabetes Risk Score

Expert Rev Mol Diagn. 2011 Nov;11(8):775-92. doi: 10.1586/erm.11.63.


Type 2 diabetes is a chronic, debilitating and often deadly disease that has reached epidemic proportions. The onset of diabetes can be delayed or prevented in high-risk individuals by diet and lifestyle changes and medications, and hence a key element for addressing the diabetes epidemic is to identify those most at risk of developing diabetes so that preventative measures can be effectively focused. The PreDx(®) Diabetes Risk Score is a multimarker tool for assessing a patient's risk of developing diabetes within the next 5 years. Requiring a simple blood draw using standard sample collection and handling procedures, the PreDx Diabetes Risk Score is easily implemented in clinical practice and provides an assessment of diabetes risk that is superior to other measures, including fasting plasma glucose, glycated hemoglobin, measures of insulin resistance and other clinical measures. In this article, we provide an overview of the PreDx Diabetes Risk Score.

MeSH terms

  • Adiponectin / blood
  • Biomarkers / blood*
  • Blood Glucose / analysis
  • C-Reactive Protein / biosynthesis
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / diagnosis*
  • Diabetes Mellitus, Type 2 / diet therapy
  • Diabetes Mellitus, Type 2 / prevention & control
  • Female
  • Ferritins / blood
  • Glycated Hemoglobin A / biosynthesis
  • Humans
  • Insulin / blood
  • Interleukin-2 Receptor alpha Subunit / blood
  • Life Style
  • Male
  • Reagent Kits, Diagnostic
  • Risk
  • Risk Assessment


  • Adiponectin
  • Biomarkers
  • Blood Glucose
  • Glycated Hemoglobin A
  • Insulin
  • Interleukin-2 Receptor alpha Subunit
  • Reagent Kits, Diagnostic
  • hemoglobin A1c protein, human
  • C-Reactive Protein
  • Ferritins