Introduction: Persistent genital arousal disorder (PGAD) is a rare condition in women that causes a lot of suffering. The pathophysiology is not well understood and an approach promising effective treatment has not been established so far.
Aim: This study aims to make colleagues aware of two treatment options, which proved to be successful in one case each and which might be worth further investigation.
Main outcome measures: Subjective distress from unwanted sexual arousal, unwanted orgasms, and pain in the genital area.
Methods: Treatment of two women--36 and 41 years old--suffering from PGAD with duloxetine and pregabalin, respectively.
Results: In both women, the treatment proved to be very successful over a long period of time. One of them experienced full remission (duloxetine) and the other one experienced substantial improvement (pregabalin), over a period now lasting for more than a year.
Conclusion: Pregabalin and duloxetine, in particular, should be further investigated as possible medication for the treatment of PGAD.
© 2011 International Society for Sexual Medicine.