Long-term outcome of cardiac pacing in octogenarians and nonagenarians

Europace. 2012 Apr;14(4):502-8. doi: 10.1093/europace/eur329. Epub 2011 Oct 23.


Aims: The number of patients >80 years receiving pacemakers (PMs) is increasing. Little is known about survival and complications in this specific subgroup. We aim to determine predictors of long-term survival.

Methods and results: Pacemaker-related complications and death occurring in patients receiving a first PM for conventional bradycardia indications were systematically documented (the FollowPace registry). This report describes 481 patients ≥80 years during a mean follow-up of 5.8 (SD 1.2) years. Within 2 months 54 PM complications occurred in 47 patients (9.8%). During follow-up, 35 adverse PM events were reported in 33 patients (6.9%). Complication rates in patients ≥80 years were comparable with those for patients <80 years. Survival rates were 86, 75, and 49% after 1, 2, and 5 years, respectively, and were comparable with survival for age- and sex-matched controls from the general Dutch population. Most patients died of non-cardiac causes. Age at the time of implantation, male gender, the presence of congestive heart failure, coronary pathology, and diabetes mellitus were independent predictors of all-cause mortality.

Conclusion: This large study of long-term cardiac pacing for bradycardia in octogenarians and nonagenarians showed a cumulative 5-year survival of ~50%, which compares with that of age- and sex-matched controls. These data suggest a beneficial impact of bradycardia pacing, restoring life expectancy to previous levels. The occurrence of PM complications during long-term follow-up is not infrequent with 18.1% of patients experiencing a PM-related complication during a mean of 5.8 years follow-up. The complication rate was not higher than in younger PM patients.

Trial registration: ClinicalTrials.gov NCT00135174.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged, 80 and over
  • Bradycardia / mortality*
  • Bradycardia / prevention & control*
  • Cardiac Pacing, Artificial / mortality*
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Netherlands / epidemiology
  • Prevalence
  • Risk Assessment
  • Risk Factors
  • Sex Distribution
  • Survival Analysis
  • Survival Rate
  • Treatment Outcome

Associated data

  • ClinicalTrials.gov/NCT00135174