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Randomized Controlled Trial
. 2011 Dec;94(6):1479-84.
doi: 10.3945/ajcn.111.022426. Epub 2011 Oct 26.

Cheese Intake in Large Amounts Lowers LDL-cholesterol Concentrations Compared With Butter Intake of Equal Fat Content

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Randomized Controlled Trial

Cheese Intake in Large Amounts Lowers LDL-cholesterol Concentrations Compared With Butter Intake of Equal Fat Content

Julie Hjerpsted et al. Am J Clin Nutr. .

Abstract

Background: Despite its high content of saturated fatty acids, cheese does not seem to increase plasma total and LDL-cholesterol concentrations when compared with an equivalent intake of fat from butter. This effect may be due to the high calcium content of cheese, which results in a higher excretion of fecal fat.

Objectives: The objective was to compare the effects of diets of equal fat content rich in either hard cheese or butter or a habitual diet on blood pressure and fasting serum blood lipids, C-reactive protein, glucose, and insulin. We also examined whether fecal fat excretion differs with the consumption of cheese or butter.

Design: The study was a randomized dietary intervention consisting of two 6-wk crossover periods and a 14-d run-in period during which the subjects consumed their habitual diet. The study included 49 men and women who replaced part of their habitual dietary fat intake with 13% of energy from cheese or butter.

Results: After 6 wk, the cheese intervention resulted in lower serum total, LDL-, and HDL-cholesterol concentrations and higher glucose concentrations than did the butter intervention. Cheese intake did not increase serum total or LDL-cholesterol concentrations compared with the run-in period, during which total fat and saturated fat intakes were lower. Fecal fat excretion did not differ between the cheese and butter periods.

Conclusion: Cheese lowers LDL cholesterol when compared with butter intake of equal fat content and does not increase LDL cholesterol compared with a habitual diet. This trial is registered at clinicaltrials.gov as NCT01140165.

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