Lymphadenectomy influences the utilization of adjuvant radiation treatment for endometrial cancer

Am J Obstet Gynecol. 2011 Dec;205(6):562.e1-9. doi: 10.1016/j.ajog.2011.09.001. Epub 2011 Sep 16.


Objective: We analyzed the effect of lymphadenectomy on the use of adjuvant radiation treatment for women with stage I-II endometrial cancer.

Study design: Women with stage I-II endometrioid adenocarcinomas treated between 1988 and 2006 and recorded in the Surveillance, Epidemiology, and End Results database were identified. The influence of lymphadenectomy (LND) on receipt of external beam radiation and brachytherapy stratified was examined.

Results: We identified 58,776 women including 26,043 who underwent LND (44.3%). Among women younger than 60 years of age with stage IA (grades 1, 2, and 3) tumors, LND had no impact on the use of radiation. Patients with stage IB (grade 2 or 3) and stage IC (grade 1 or 2) tumors who underwent lymph node dissection were less likely to undergo external beam radiation and more likely to receive vaginal brachytherapy (P < .05 for all). Furthermore, the extent of lymphadenectomy influenced the receipt of radiation.

Conclusion: Women who undergo lymphadenectomy are less likely to receive whole pelvic radiotherapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brachytherapy / adverse effects
  • Brachytherapy / statistics & numerical data
  • Endometrial Neoplasms / epidemiology*
  • Endometrial Neoplasms / pathology
  • Endometrial Neoplasms / radiotherapy*
  • Endometrial Neoplasms / surgery
  • Female
  • Humans
  • Lymph Node Excision / statistics & numerical data*
  • Middle Aged
  • Neoplasm Staging / statistics & numerical data
  • Pelvis
  • Radiotherapy, Adjuvant / statistics & numerical data*
  • Risk Factors
  • SEER Program / statistics & numerical data
  • Vagina