Squamous-cell carcinoma in situ in a patient with oculocutaneous albinism

Dermatol Online J. 2011 Oct 15;17(10):22.

Abstract

A 36-year-old African man from Guinea with a history of albinism presented with a many-year history of scaling and erythema of the face, neck, and arms. The patient had light eyes, hair, and skin. Physical examination showed extensive photodamage. A skin biopsy specimen from the posterior aspect of the lower leg showed a squamous-cell carcinoma in situ. The most common types of oculocutaneous albinism (OCA), OCA 1 and OCA 2, are autosomal recessive disorders of pigmentation that commonly affect the skin, hair, eyes, and ears. Photodamage and skin cancers plague patients with albinism. In Africa, where albinism is prevalent, albinos face a myriad of social and medical issues. Skin cancer surveillance is an important consideration for albinos, and sun protection is paramount.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Albinism, Oculocutaneous / complications*
  • Albinism, Oculocutaneous / ethnology
  • Albinism, Oculocutaneous / genetics
  • Albinism, Oculocutaneous / psychology
  • Carcinoma in Situ / diagnosis
  • Carcinoma in Situ / etiology*
  • Carcinoma in Situ / pathology
  • Carcinoma, Squamous Cell / diagnosis
  • Carcinoma, Squamous Cell / etiology*
  • Carcinoma, Squamous Cell / pathology
  • Disease Susceptibility
  • Guinea / ethnology
  • Humans
  • Leg
  • Male
  • Neoplasms, Radiation-Induced / diagnosis
  • Neoplasms, Radiation-Induced / etiology*
  • Neoplasms, Radiation-Induced / pathology
  • Prejudice
  • Prevalence
  • Radiation Tolerance / genetics
  • Skin Neoplasms / diagnosis
  • Skin Neoplasms / etiology*
  • Skin Neoplasms / pathology
  • Sunburn
  • Sunlight / adverse effects*
  • Sunscreening Agents

Substances

  • Sunscreening Agents