[Mood disorder after malaria prophylaxis with mefloquine (two case reports)]

Encephale. 2011 Oct;37(5):393-6. doi: 10.1016/j.encep.2011.01.013. Epub 2011 Mar 25.
[Article in French]


Introduction: Mefloquine (Lariam) is the drug of choice as malaria prophylaxis for travel to chloroquine-resistant areas. Severe neuropsychiatric side effects are rare. We report two clinical cases of mood disorders: mania and a major depressive episode with psychotic characteristics in two patients with mefloquine antimalarial prophylaxis. FIRST CLINICAL CASE: A 31-year-old man had taken mefloquine at a rate of 250mg/week as malaria prophylaxis for his mission in Democratic Republic of Congo. He developed mania with psychotic symptoms after taking five tablets of 250mg of mefloquine. He exhibited an elevated mood and also developed delusions of grandeur, reference and persecution, with auditory hallucinations. The physical examination and the blood laboratory tests were normal. The patient was treated with an atypical neuroleptic (olanzapine 20mg/d) leading to a complete resolution of symptomatology at the end of 3 weeks. SECOND CLINICAL CASE: A 27-year-old man presented a major depressive episode with psychotic symptoms after 1 week on his return from a stay in Democratic Republic of Congo, where he had taken mefloquine during 6 months as malaria prophylaxis (250mg/week). His physical examination and investigations (full blood test, serology and MRN) were normal. The patient was treated with clomipramine (150mg/d) and olanzapine (20mg/d). The outcome was favorable after 4 weeks.

Discussion: Mefloquine is widely accepted as a safe and effective treatment and a prophylactic agent for chlorquine-resistant malaria. Common neuropsychiatric adverse effects of mefloquine can occur in up to 40% of patients, such as dizziness, sleep disturbances, anorexia, ataxia, and fatigue. Other more serious adverse reactions are rare. They are represented primarily by panic attacks, convulsions, acute psychosis, paranoid delusions, suicidal ideation, disorders of mood: major depressive episode and the manic excitation. The incidence of such neuropsychiatric effects is 1/10,000 to 1/15,000 during the prophylactic treatment. The causal mechanism for the side effects is not known. Several risk factors increasing the neurotoxicity of mefloquine can be identified, the patient with personal or family history of psychiatric disorders are more frequently concerned. Alcohol and the association with other drugs (like quinine) are two other risk factors.

Conclusion: It is relevant for medical practitioners to be aware of the severe neuropsychiatric side effects of mefloquine as malaria prophylaxis. It requires investigation of the risk factors such as personal or family history of psychiatric disorders.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antimalarials / administration & dosage
  • Antimalarials / adverse effects*
  • Antipsychotic Agents / therapeutic use
  • Benzodiazepines / therapeutic use
  • Bipolar Disorder / chemically induced*
  • Bipolar Disorder / diagnosis
  • Bipolar Disorder / drug therapy
  • Bipolar Disorder / psychology
  • Clomipramine / therapeutic use
  • Depressive Disorder, Major / chemically induced*
  • Depressive Disorder, Major / diagnosis
  • Depressive Disorder, Major / drug therapy
  • Drug Therapy, Combination
  • Humans
  • Malaria / prevention & control*
  • Malaria / psychology
  • Male
  • Mefloquine / administration & dosage
  • Mefloquine / adverse effects*
  • Olanzapine
  • Psychoses, Substance-Induced / diagnosis*
  • Psychoses, Substance-Induced / drug therapy
  • Psychoses, Substance-Induced / psychology


  • Antimalarials
  • Antipsychotic Agents
  • Benzodiazepines
  • Olanzapine
  • Clomipramine
  • Mefloquine