The vegetative and minimally conscious states: diagnosis, prognosis and treatment

Neurol Clin. 2011 Nov;29(4):773-86. doi: 10.1016/j.ncl.2011.07.009.


Severe acquired brain injury has profound impact on alertness, cognition, and behavior. Among those who survive the initial injury, a significant minority fail to fully recover self and environmental awareness, and go on to experience prolonged disorders of consciousness (DOC) that can last a lifetime. Although there are no standards of care to guide clinical management, a growing body of empirical evidence is beginning to accrue to inform clinical decision making. In this article, we review the state of the science as it pertains to diagnosis, prognosis, and treatment of patients with DOC.

Publication types

  • Historical Article
  • Review

MeSH terms

  • Disease Progression
  • History, 19th Century
  • Humans
  • Persistent Vegetative State / diagnosis*
  • Persistent Vegetative State / history
  • Persistent Vegetative State / therapy*