Iron metabolism and the innate immune response to infection

Microbes Infect. 2012 Mar;14(3):207-16. doi: 10.1016/j.micinf.2011.10.001. Epub 2011 Oct 20.

Abstract

Host antimicrobial mechanisms reduce iron availability to pathogens. Iron proteins influencing the innate immune response include hepcidin, lactoferrin, siderocalin, haptoglobin, hemopexin, Nramp1, ferroportin and the transferrin receptor. Numerous global health threats are influenced by iron status and provide examples of our growing understanding of the connections between infection and iron metabolism.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Antimicrobial Cationic Peptides / metabolism
  • Carrier Proteins / metabolism
  • Cation Transport Proteins / metabolism
  • HIV / immunology
  • HIV / metabolism
  • HIV / pathogenicity
  • HIV Infections / immunology*
  • HIV Infections / virology
  • Hepcidins
  • Humans
  • Immunity, Innate*
  • Iron / metabolism*
  • Lactoferrin / metabolism
  • Malaria / immunology
  • Malaria / metabolism
  • Malaria / parasitology
  • Mycobacterium tuberculosis / immunology
  • Mycobacterium tuberculosis / metabolism
  • Mycobacterium tuberculosis / pathogenicity
  • Plasmodium / immunology
  • Plasmodium / pathogenicity
  • Tuberculosis / immunology*
  • Tuberculosis / microbiology

Substances

  • Antimicrobial Cationic Peptides
  • Carrier Proteins
  • Cation Transport Proteins
  • HAMP protein, human
  • Hepcidins
  • LCN2 protein, human
  • metal transporting protein 1
  • natural resistance-associated macrophage protein 1
  • Iron
  • Lactoferrin