Molecular functions of syndecan-1 in disease

Matrix Biol. 2012 Jan;31(1):3-16. doi: 10.1016/j.matbio.2011.10.001. Epub 2011 Oct 18.

Abstract

Syndecan-1 is a cell surface heparan sulfate proteoglycan that binds to many mediators of disease pathogenesis. Through these molecular interactions, syndecan-1 can modulate leukocyte recruitment, cancer cell proliferation and invasion, angiogenesis, microbial attachment and entry, host defense mechanisms, and matrix remodeling. The significance of syndecan-1 interactions in disease is underscored by the striking pathological phenotypes seen in the syndecan-1 null mice when they are challenged with disease-instigating agents or conditions. This review discusses the key molecular functions of syndecan-1 in modulating the onset, progression, and resolution of inflammatory diseases, cancer, and infection.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Infections / metabolism*
  • Infections / pathology
  • Inflammation / metabolism*
  • Inflammation / pathology
  • Mice
  • Mice, Knockout
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Syndecan-1 / genetics*
  • Syndecan-1 / metabolism*

Substances

  • Syndecan-1