Antimicrobial stewardship

Mayo Clin Proc. 2011 Nov;86(11):1113-23. doi: 10.4065/mcp.2011.0358.


Antimicrobial resistance is increasing; however, antimicrobial drug development is slowing. Now more than ever before, antimicrobial stewardship is of the utmost importance as a way to optimize the use of antimicrobials to prevent the development of resistance and improve patient outcomes. This review describes the why, what, who, how, when, and where of antimicrobial stewardship. Techniques of stewardship are summarized, and a plan for implementation of a stewardship program is outlined.

MeSH terms

  • Algorithms
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / therapeutic use*
  • Decision Support Techniques
  • Drug Resistance, Microbial
  • Drug Utilization / standards*
  • Drug Utilization Review / organization & administration
  • Formularies as Topic
  • Humans
  • Pharmacy Service, Hospital / organization & administration*
  • Pharmacy Service, Hospital / standards
  • Practice Guidelines as Topic
  • Quality Assurance, Health Care / organization & administration*
  • Quality Assurance, Health Care / standards
  • United States


  • Anti-Bacterial Agents