Existence of manserin, a secretogranin II-derived neuropeptide, in the rat inner ear: relevance to modulation of auditory and vestibular system

J Histochem Cytochem. 2012 Jan;60(1):69-75. doi: 10.1369/0022155411425688. Epub 2011 Oct 27.


Manserin is a 40-amino acid neuropeptide derived from rat brain. Manserin has been shown to distribute in the neuroendocrine system, such as the pituitary and adrenal glands, but it has been little studied in other organs. In this study, the authors examined localization of manserin in the inner ear of the adult Wistar rat using immunohistochemical analyses. Manserin immunoreactivity was detected in the neuronal terminals of the organ of Corti and type II spiral ganglion cells. In addition to being identified in the auditory system, manserin was detected at the synapses of the vestibular system, such as saccule, utricle, and semicircular canal. These results suggest that inner ear manserin may be involved in the function of peripheral auditory and vestibular systems.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Auditory Pathways / metabolism
  • Ear, Inner / metabolism*
  • Immunohistochemistry
  • Male
  • Neuropeptides / metabolism*
  • Organ Specificity
  • Organ of Corti / metabolism
  • Peptide Fragments / metabolism*
  • Rats
  • Rats, Wistar
  • Secretogranin II / metabolism*
  • Spiral Ganglion / cytology
  • Spiral Ganglion / metabolism
  • Vestibule, Labyrinth / metabolism


  • Neuropeptides
  • Peptide Fragments
  • Secretogranin II
  • manserin, rat
  • secretogranin 2, rat