Inverted papilloma with associated carcinoma of the nasal cavity and paranasal sinuses: treatment outcomes

Acta Otolaryngol. 2012 Jan;132(1):80-5. doi: 10.3109/00016489.2011.620001. Epub 2011 Oct 30.


Conclusions: Degenerated inverted papilloma is a rare, aggressive, and lethal disease. To avoid missing the target, it is absolutely necessary to consider the microscopic extension even in cases of complete exeresis and to irradiate the whole of the adjacent sinuses. A dose increase may lead to better locoregional control.

Objective: To evaluate overall survival and progression-free survival of external radiotherapy in the management of nasal cavity and paranasal sinus inverted papilloma with associated carcinoma.

Methods: Clinical data from 11 patients treated by surgery followed by external radiotherapy (three-dimensional conformational radiotherapy until 2007 then intensity-modulated radiation therapy) for degenerated inverted papilloma in the Léon Bérard Cancer Centre between 1985 and 2009 were retrospectively analyzed.

Results: Five patients (45%) had a local recurrence and died from their recurrence. Three had a premature recurrence, just before or during radiotherapy. We could not determine the prognostic factors for overall survival and progression-free survival.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Carcinoma / diagnosis
  • Carcinoma / mortality
  • Carcinoma / therapy*
  • Combined Modality Therapy
  • Female
  • Follow-Up Studies
  • France / epidemiology
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / epidemiology
  • Neoplasms, Multiple Primary / diagnosis
  • Neoplasms, Multiple Primary / mortality
  • Neoplasms, Multiple Primary / therapy*
  • Nose Neoplasms / diagnosis
  • Nose Neoplasms / mortality
  • Nose Neoplasms / therapy*
  • Papilloma, Inverted / diagnosis
  • Papilloma, Inverted / mortality
  • Papilloma, Inverted / therapy*
  • Paranasal Sinus Neoplasms / diagnosis
  • Paranasal Sinus Neoplasms / mortality
  • Paranasal Sinus Neoplasms / therapy*
  • Retrospective Studies
  • Survival Rate / trends
  • Time Factors
  • Tomography, X-Ray Computed
  • Treatment Outcome