Tailor-made peptide synthetases

Hajo Kries; Donald Hilvert

doi:10.1016/j.chembiol.2011.10.006

Tailor-made peptide synthetases

Chem Biol. 2011 Oct 28;18(10):1206-7. doi: 10.1016/j.chembiol.2011.10.006.

Authors

Hajo Kries¹, Donald Hilvert

Affiliation

¹ Laboratory of Organic Chemistry, ETH Zürich, CH-8093 Zurich, Switzerland.

PMID: 22035787
DOI: 10.1016/j.chembiol.2011.10.006

Abstract

Harnessing the modular architecture of non-ribosomal peptide synthetases for combinatorial biosynthesis is a longstanding goal in chemical biology. Several recent reports illustrate how computational design and directed evolution can be used to tailor the specificity of these assembly-line enzymes.

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