Evidence for functional trace amine associated receptor-1 in normal and malignant B cells

Leuk Res. 2012 Feb;36(2):245-9. doi: 10.1016/j.leukres.2011.10.002. Epub 2011 Oct 27.


Following the observation that dopaminergic components are present in normal and malignant B cells, we now provide evidence that they additionally express the functionally related trace amine-associated receptor-1 (TAAR1). Immunodetectable TAAR1 was found in lines derived from a broad range of B-cell malignancy; and in tonsillar B cells, particularly when activated. L3055 Burkitt's lymphoma cells were shown to respond to prototypical TAAR1 agonists in cytotoxicity assays with features of apoptotic death evident; normal B cells were somewhat less sensitive to the agonists. These data raise the possibility that TAAR1 may have therapeutic relevance to leukemia, lymphoma, and wider B-cell pathologies.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apoptosis / drug effects
  • B-Lymphocytes / metabolism*
  • Blotting, Western
  • Burkitt Lymphoma / metabolism*
  • Burkitt Lymphoma / pathology
  • Cell Proliferation / drug effects
  • Cells, Cultured
  • Dopamine / metabolism
  • Flow Cytometry
  • Humans
  • Palatine Tonsil / cytology
  • Palatine Tonsil / drug effects
  • Palatine Tonsil / metabolism*
  • Receptors, G-Protein-Coupled / agonists*
  • Receptors, G-Protein-Coupled / metabolism*


  • Receptors, G-Protein-Coupled
  • Dopamine
  • Trace amine-associated receptor 1