Dueling Ca2+ sensors in neurotransmitter release

Mingshan Xue; Nikolaos Giagtzoglou; Hugo J Bellen

doi:10.1016/j.cell.2011.10.007

Dueling Ca2+ sensors in neurotransmitter release

Cell. 2011 Oct 28;147(3):491-3. doi: 10.1016/j.cell.2011.10.007.

Authors

Mingshan Xue¹, Nikolaos Giagtzoglou, Hugo J Bellen

Affiliation

¹ Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.

Abstract

Ca(2+)-triggered neurotransmitter release is characterized by two kinetically distinct components: a fast synchronous phase and a slow asynchronous phase. Yao et al. (2011) now report that double C2 domain (Doc2) proteins function as high-affinity Ca(2+) sensors to specifically regulate the asynchronous component of neurotransmitter release.

Publication types

Comment

Grants and funding

HHMI/Howard Hughes Medical Institute/United States