Detoxification of high-dose zolpidem using cross-titration with an adequate equivalent dose of diazepam

Gen Hosp Psychiatry. 2012 Mar-Apr;34(2):210.e5-7. doi: 10.1016/j.genhosppsych.2011.09.012. Epub 2011 Oct 28.


Background: There have been numerous case reports of zolpidem abuse and dependence in the recent decade, giving rise to a focus on adverse withdrawal events such as seizure. No standard detoxification regimen has been proposed to date, despite the similarity of effects of zolpidem and benzodiazepines at high doses.

Case descriptions: We describe the results, in a 53-year-old female patient, of undergoing three different zolpidem detoxification programs.

Conclusions: Because of her experiences, we recommend using the cross-titration strategy with an adequate equivalent dose of diazepam.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Diazepam / administration & dosage*
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Hypnotics and Sedatives / administration & dosage*
  • Hypnotics and Sedatives / poisoning*
  • Inactivation, Metabolic
  • Male
  • Middle Aged
  • Pyridines / administration & dosage*
  • Pyridines / poisoning*
  • Zolpidem


  • Hypnotics and Sedatives
  • Pyridines
  • Zolpidem
  • Diazepam