Subclinical hypothyroidism: a review of neuropsychiatric aspects

Int J Psychiatry Med. 1990;20(2):193-208. doi: 10.2190/ADLY-1UU0-1A8L-HPXY.


The authors review current information about the prevalence, causes, course, and consequences of subclinical hypothyroidism. There is evidence that subclinical hypothyroidism may be associated with cognitive dysfunction, mood disturbance, and diminished response to standard psychiatric treatments. Recommendations are presented for the screening, evaluation and treatment of patients in whom subclinical hypothyroidism may be contributing to neuropsychiatric dysfunction.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Humans
  • Hypothyroidism / diagnosis
  • Hypothyroidism / psychology*
  • Neurocognitive Disorders / diagnosis
  • Neurocognitive Disorders / psychology*
  • Neuropsychological Tests*
  • Risk Factors
  • Thyroid Function Tests