Association of the ADRA1A gene and the severity of metabolic abnormalities in patients with schizophrenia

Prog Neuropsychopharmacol Biol Psychiatry. 2012 Jan 10;36(1):205-10. doi: 10.1016/j.pnpbp.2011.10.011. Epub 2011 Oct 20.


Patients with schizophrenia have a higher risk of developing metabolic abnormalities and their associated diseases. Some studies found that the accumulative number of metabolic syndrome components was associated with the severity of metabolic abnormalities. The purpose of this study was to examine the roles of the ADRA1A, ADRA2A, ADRB3, and 5HT2A genes in the risk of having more severe metabolic abnormalities among patients with schizophrenia. We studied a sample of 232 chronic inpatients with schizophrenia (120 males and 112 females) to explore the associations between the four candidate genes and the severity of metabolic syndrome by accumulative number of the components. Four single nucleotide polymorphisms in the candidate genes were genotyped, including the Arg347Cys in ADRA1A, the C1291G in ADRA2A, the Try64Arg in ADRB3, and the T102C in 5HT2A. An association between the accumulative number of metabolic syndrome components and the ADRA1A gene was found after adjusting age, sex, and other related variables (p-value=0.036). Presence of the Arg347 allele in the ADRA1A gene is a risk factor for having more severe metabolic abnormalities. These findings suggest a medical attention of closely monitoring metabolic risks for schizophrenia patients with high-risk genotypes.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Arginine / genetics
  • Cysteine / genetics
  • Female
  • Gene Frequency
  • Genetic Association Studies* / methods
  • Humans
  • Male
  • Metabolic Syndrome / diagnosis
  • Metabolic Syndrome / epidemiology
  • Metabolic Syndrome / genetics*
  • Middle Aged
  • Polymorphism, Single Nucleotide / genetics
  • Receptors, Adrenergic, alpha-1 / genetics*
  • Risk Factors
  • Schizophrenia / epidemiology
  • Schizophrenia / genetics*
  • Schizophrenia / metabolism
  • Severity of Illness Index*


  • ADRA1A protein, human
  • Receptors, Adrenergic, alpha-1
  • Arginine
  • Cysteine