A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1

Nat Genet. 2011 Oct 30;43(12):1215-8. doi: 10.1038/ng.978.

Abstract

Gastric cancer, including the cardia and non-cardia types, is the second leading cause of cancer-related deaths worldwide. To identify genetic risk variants for non-cardia gastric cancer, we performed a genome-wide association study in 3,279 individuals (1,006 with non-cardia gastric cancer and 2,273 controls) of Chinese descent. We replicated significant associations in an additional 6,897 subjects (3,288 with non-cardia gastric cancer and 3,609 controls). We identified two new susceptibility loci for non-cardia gastric cancer at 5p13.1 (rs13361707 in the region including PTGER4 and PRKAA1; odds ratio (OR) = 1.41; P = 7.6 × 10(-29)) and 3q13.31 (rs9841504 in ZBTB20; OR = 0.76; P = 1.7 × 10(-9)). Imputation analyses also confirmed previously reported associations of rs2294008 and rs2976392 on 8q24, rs4072037 on 1q22 and rs13042395 on 20p13 with non-cardia gastric cancer susceptibility in the Han Chinese population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • AMP-Activated Protein Kinases / genetics*
  • Adult
  • Aged
  • Case-Control Studies
  • Chromosomes, Human, Pair 3 / genetics*
  • Chromosomes, Human, Pair 5 / genetics*
  • Female
  • Genetic Loci
  • Genome-Wide Association Study
  • Humans
  • Male
  • Middle Aged
  • Nerve Tissue Proteins / genetics
  • Odds Ratio
  • Polymorphism, Single Nucleotide
  • Receptors, Prostaglandin E, EP4 Subtype / genetics*
  • Stomach Neoplasms / genetics*
  • Transcription Factors / genetics

Substances

  • Nerve Tissue Proteins
  • PTGER4 protein, human
  • Receptors, Prostaglandin E, EP4 Subtype
  • Transcription Factors
  • ZBTB20 protein, human
  • PRKAA1 protein, human
  • AMP-Activated Protein Kinases