Anatomical relationships between the ventral mesencephalic tegmentum--a 10 region and the locus coeruleus as demonstrated by anterograde and retrograde tracing techniques

J Neural Transm. 1979;44(1-2):77-86. doi: 10.1007/BF01252703.


We have searched for anatomical connections between the ventral mesencephalic tegmentum (VMT), including the dopaminergic cell group A10 and the locus coeruleus (LC) region. Tritiated leucine (120--220 nl) and horseradish peroxidase delivered by electrophoresis were injected in the VMT-A10 region. We have demonstrated, on the one hand bilateral projections from the VMT-A10 region to LC, and on the other hand a possible contralateral projection from LC to VMT-A10 region. These relationships, reported for the first time may have some important functional significance.

MeSH terms

  • Animals
  • Dopamine
  • Horseradish Peroxidase / pharmacology
  • Isotope Labeling
  • Leucine / pharmacology
  • Locus Coeruleus / anatomy & histology*
  • Male
  • Neural Pathways
  • Rats
  • Synaptic Transmission / drug effects
  • Tegmentum Mesencephali / anatomy & histology*


  • Horseradish Peroxidase
  • Leucine
  • Dopamine