Curaxins: a new family of non-genotoxic multitargeted anticancer agents

ChemMedChem. 2011 Dec 9;6(12):2133-6. doi: 10.1002/cmdc.201100476. Epub 2011 Oct 28.
No abstract available

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use
  • Carbazoles / chemistry
  • Carbazoles / pharmacology
  • Carbazoles / therapeutic use
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • DNA / metabolism
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / metabolism
  • High Mobility Group Proteins / chemistry
  • High Mobility Group Proteins / metabolism
  • Humans
  • Mice
  • Microsomes, Liver / metabolism
  • NF-kappa B / antagonists & inhibitors
  • NF-kappa B / metabolism
  • Neoplasms / drug therapy
  • Transcriptional Elongation Factors / chemistry
  • Transcriptional Elongation Factors / metabolism
  • Tumor Suppressor Protein p53 / agonists
  • Tumor Suppressor Protein p53 / metabolism

Substances

  • Antineoplastic Agents
  • Carbazoles
  • DNA-Binding Proteins
  • High Mobility Group Proteins
  • NF-kappa B
  • SSRP1 protein, human
  • Transcriptional Elongation Factors
  • Tumor Suppressor Protein p53
  • DNA