Derangement of neuronal migration in a child with multiple congenital anomalies, two congenital neoplasms, without apparent chromosomal abnormalities

J Neuropathol Exp Neurol. 1979 May;38(3):259-85. doi: 10.1097/00005072-197905000-00007.

Abstract

A live-born male infant with multiple severe abnormalities, two congenital neoplasms, a neuroblastoma and nephroblastoma, and without apparent chromosomal abnormalities, is described. The neuropathologic findings were a holoprosencephalic type defect with disturbance of neuronal migration to the cortical plate. Comparison of the overall findings with cases presenting similar multiple congenital abnormalities indicates that this case either demonstrates previously unrecognized features of these syndromes, or is unique.

Publication types

  • Case Reports

MeSH terms

  • Abnormalities, Multiple / pathology*
  • Brain / abnormalities
  • Brain / pathology
  • Cell Movement*
  • Chromosome Aberrations / pathology*
  • Chromosome Disorders
  • Humans
  • Infant, Newborn
  • Kidney / pathology
  • Kidney Neoplasms / congenital*
  • Kidney Neoplasms / pathology
  • Male
  • Neoplasms, Multiple Primary / pathology
  • Neuroblastoma / congenital*
  • Neuroblastoma / pathology
  • Spinal Neoplasms / congenital*
  • Spinal Neoplasms / pathology
  • Spine / pathology
  • Wilms Tumor / congenital*
  • Wilms Tumor / pathology