Autoradiographic localization of mas proto-oncogene mRNA in adult rat brain using in situ hybridization

Neurosci Lett. 1990 Jul 3;114(2):147-53. doi: 10.1016/0304-3940(90)90063-f.


The cellular localization and the distribution of the mas proto-oncogene/angiotensin receptor mRNA have been studied in the male rat brain using in situ hybridization with radiolabelled mas cRNA probes. Neuronal cell populations in the forebrain were selectively labelled. A strong specific labelling was demonstrated in the dentate gyrus, the CA3 and CA4 areas of the hippocampus, the olfactory tubercle (medical part), the piriform cortex and the olfactory bulb, while a weak to moderate labelling was present all over the neocortex and especially in the frontal lobe.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Autoradiography
  • Brain / cytology
  • Brain / enzymology*
  • Male
  • Neoplasm Proteins / genetics*
  • Nucleic Acid Hybridization
  • Organ Specificity
  • Protein-Tyrosine Kinases / genetics
  • Proto-Oncogene Mas
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogenes*
  • RNA, Messenger / analysis
  • RNA, Messenger / genetics*
  • Rats
  • Rats, Inbred Strains
  • Receptors, G-Protein-Coupled
  • Sulfur Radioisotopes
  • Uridine Triphosphate / metabolism


  • Neoplasm Proteins
  • Proto-Oncogene Mas
  • Proto-Oncogene Proteins
  • RNA, Messenger
  • Receptors, G-Protein-Coupled
  • Sulfur Radioisotopes
  • Protein-Tyrosine Kinases
  • Uridine Triphosphate