Toward an image-guided microbeam radiation therapy using gadolinium-based nanoparticles

ACS Nano. 2011 Dec 27;5(12):9566-74. doi: 10.1021/nn202797h. Epub 2011 Nov 9.


Ultrasmall gadolinium-based nanoparticles (GBNs) induce both a positive contrast for magnetic resonance imaging and a radiosentizing effect. The exploitation of these characteristics leads to a greater increase in lifespan of rats bearing brain tumors since the radiosensitizing effect of GBNs can be activated by X-ray microbeams when the gadolinium content is, at the same time, sufficiently high in the tumor and low in the surrounding healthy tissue. GBNs exhibit therefore an interesting potential for image-guided radiotherapy.

MeSH terms

  • Animals
  • Brain Neoplasms / pathology*
  • Brain Neoplasms / radiotherapy*
  • Contrast Media / therapeutic use
  • Gadolinium / therapeutic use*
  • Nanoparticles / therapeutic use*
  • Radiotherapy, Conformal / methods*
  • Radiotherapy, Image-Guided / methods*
  • Rats
  • Treatment Outcome


  • Contrast Media
  • Gadolinium