Evaluation of Antihyperglycemic Activity of Cocos Nucifera Linn. On Streptozotocin Induced Type 2 Diabetic Rats

J Ethnopharmacol. 2011 Dec 8;138(3):769-73. doi: 10.1016/j.jep.2011.10.021. Epub 2011 Oct 20.


Ethnopharmacological relevance: The plant Cocos nucifera Linn. (Arecaceae) is commonly known as coconut. Traditionally the juice of the young spadix when fresh is used in diarrhea and diabetes. The objective of the present study was to investigate the effect of antidiabetic activity and effect on lipid profile as well as cardioprotective effect of hydro-methanol extract of Cocos nucifera (HECN) on streptozotocin (STZ)-induced diabetic rats.

Materials and methods: After 72 h of STZ (50 mg/kg, b.w. i.p.) administration, animals showing plasma sugar level more than 250 mg/dl were considered as diabetic rat. Fasting blood glucose (FBG) levels were measured on 0th (after 72 h of STZ), 5th, 10th, and 15th day. On the 15th day all the animals were sacrificed and the serum biochemical parameters and antioxidant enzyme status were measured.

Results: HECN treated animals showed a significant reduction in FBG level as compared with diabetic control group. Serum enzyme level (SGOT, SGPT, SALP), lipid peroxidation and antioxidant enzyme level such as CAT, GSH, SOD and cholesterol and triglycerides in the HECN treated groups were restored towards normal level as compared to diabetic control groups and the values were comparable with the standard groups (glibenclamide).

Conclusion: Improvement in the FBG and the restoration of all other biomarker as well as enzymes indicates that HECN has very good antidiabetic activity with very low side effects and provides a scientific rationale for the use as an antidiabetic agent.

MeSH terms

  • Alanine Transaminase / blood
  • Alkaline Phosphatase / blood
  • Animals
  • Aspartate Aminotransferases / blood
  • Blood Glucose / analysis
  • Catalase / metabolism
  • Cocos*
  • Diabetes Mellitus, Experimental / drug therapy*
  • Diabetes Mellitus, Experimental / metabolism
  • Female
  • Glutathione / metabolism
  • Hypoglycemic Agents / therapeutic use*
  • Hypoglycemic Agents / toxicity
  • Lipid Peroxidation / drug effects
  • Lipids / blood
  • Male
  • Mice
  • Plant Extracts / therapeutic use*
  • Plant Extracts / toxicity
  • Plants, Medicinal
  • Rats
  • Rats, Wistar
  • Superoxide Dismutase / metabolism


  • Blood Glucose
  • Hypoglycemic Agents
  • Lipids
  • Plant Extracts
  • Catalase
  • Superoxide Dismutase
  • Aspartate Aminotransferases
  • Alanine Transaminase
  • Alkaline Phosphatase
  • Glutathione