Peptide sequences that target cytosolic proteins for lysosomal proteolysis

Trends Biochem Sci. 1990 Aug;15(8):305-9. doi: 10.1016/0968-0004(90)90019-8.


Lysosomes take up and degrade intracellular proteins in cultured cells in response to serum deprivation, and in tissues of organisms in response to starvation. One mechanism by which proteins enter lysosomes for subsequent degradation requires that substrate proteins contain peptide sequences biochemically related to Lys-Phe-Glu-Arg-Gln (KFERQ).

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Humans
  • Lysosomes / metabolism*
  • Molecular Sequence Data
  • Peptides / metabolism
  • Proteins / metabolism*


  • Peptides
  • Proteins