[Tracheal Allotransplantation After Withdrawal of Immunosuppressive Therapy]

Bull Acad Natl Med. 2010 Oct;194(7):1335-7; discussion 1337.
[Article in French]

Abstract

Reconstruction of long-segment tracheal defects requires a vascularized allograft. We report successful tracheal allotransplantation after indirect revascularization of the graft in a heterotopic position. Immunosuppressive therapy was administered before the operation, and the tracheal allograft was wrapped in the recipient's forearm fascia. Once revascularization was achieved, the mucosal lining was replaced progressively with buccal mucosa from the recipient. At 4 months, the tracheal chimera was fully lined with mucosa, which consisted of respiratory epithelium from the donor and buccal mucosa from the recipient. After withdrawal of immunosuppressive therapy, the tracheal allograft was moved to its correct anatomical position with an intact blood supply. No treatment-limiting adverse effects occurred.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Humans
  • Immunosuppression / methods
  • Immunosuppressive Agents / administration & dosage*
  • Immunosuppressive Agents / therapeutic use
  • Reconstructive Surgical Procedures / methods*
  • Trachea / blood supply
  • Trachea / immunology
  • Trachea / transplantation*
  • Transplantation Conditioning / methods
  • Transplantation Tolerance / immunology
  • Transplantation Tolerance / physiology
  • Transplantation, Homologous
  • Withholding Treatment

Substances

  • Immunosuppressive Agents