[Whey protein improves insulin resistance via the increase of antioxidant capacity in model rats]

Wei Sheng Yan Jiu. 2011 Sep;40(5):617-9.
[Article in Chinese]


Objective: To investigate the effects of whey protein on insulin resistance in model rats.

Methods: Insulin resistance model rats were established by feeding high-fat diet in Wistar rats. Model rats were then randomly divided into 4 groups of 10 animals each and fed on 0% whey protein (WP), 5% WP and 15% WP. After 8 weeks, fasting blood glucose (FBG), fasting plasma insulin (FINS) were determined. Oral glucose tolerance test (OGTT) was performed and glucose area under the curve (AUC) was calculated. Also, plasma total anti-oxidation capacity (T-AOC), superoxide dismutase (SOD), reduced glutathione hormone (GSH) and malondialdehyde (MDA) were determined.

Results: Whey protein intake did not affected FBG and glucose AUC. FINS and homeostatic model assessment-insulin resistance (HOMA-IR) were significantly lower in 15% WP group than in 0% WP group. For antioxidant index,plasma level of T-AOC, SOD and GSH were significantly higher in 15% WP group than in 0% WP group (T-AOC : P < 0.01; SOD, GSH : P < 0.05); however, MDA was significantly lower in 15% WP group than in 0% WP group (P < 0.05).

Conclusion: Whey protein improves insulin resistance. This effect is related to the increase of antioxidant capacity in insulin resistance model rats.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / metabolism*
  • Dietary Fats / administration & dosage*
  • Insulin Resistance / physiology*
  • Male
  • Milk Proteins / pharmacology*
  • Rats
  • Rats, Wistar
  • Whey Proteins


  • Antioxidants
  • Dietary Fats
  • Milk Proteins
  • Whey Proteins