Abstract
Axitinib, an oral small-molecule tyrosine kinase inhibitor targeted to angiogenesis, has demonstrated activity in advanced renal cell carcinoma. Common side effects include hypertension, fatigue and dysphonia. Axitinib is currently awaiting approval as a second-line agent in the treatment of advanced renal cell carcinoma. Trials, which include treatment-naive patients, are ongoing and will study the benefit of axitinib in the first-line setting.
MeSH terms
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Antineoplastic Agents / adverse effects
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Antineoplastic Agents / pharmacology
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Antineoplastic Agents / therapeutic use*
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Axitinib
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Carcinoma, Renal Cell / drug therapy*
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Carcinoma, Renal Cell / secondary
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Clinical Trials, Phase I as Topic
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Clinical Trials, Phase II as Topic
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Clinical Trials, Phase III as Topic
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Humans
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Imidazoles / adverse effects
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Imidazoles / chemistry
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Imidazoles / pharmacology
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Imidazoles / therapeutic use*
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Indazoles / adverse effects
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Indazoles / chemistry
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Indazoles / pharmacology
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Indazoles / therapeutic use*
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Kidney Neoplasms / drug therapy*
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Kidney Neoplasms / pathology
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Receptors, Vascular Endothelial Growth Factor / antagonists & inhibitors
Substances
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Antineoplastic Agents
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Imidazoles
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Indazoles
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Axitinib
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Receptors, Vascular Endothelial Growth Factor