Regulation of neutrophil trafficking from the bone marrow

Cell Mol Life Sci. 2012 May;69(9):1415-23. doi: 10.1007/s00018-011-0870-8. Epub 2011 Nov 2.


Neutrophils are an essential component of the innate immune response and a major contributor to inflammation. Consequently, neutrophil homeostasis in the blood is highly regulated. Neutrophil number in the blood is determined by the balance between neutrophil production in the bone marrow and release from the bone marrow to blood with neutrophil clearance from the circulation. This review will focus on mechanisms regulating neutrophil release from the bone marrow. In particular, recent data demonstrating a central role for the chemokines CXCL12 and CXCL2 in regulating neutrophil egress from the bone marrow will be discussed.

Publication types

  • Review

MeSH terms

  • Animals
  • Bone Marrow / physiology*
  • Cell Adhesion Molecules / physiology
  • Cell Movement
  • Homeostasis
  • Humans
  • Mice
  • Models, Biological
  • Neutrophils / physiology*
  • Peptide Hydrolases / physiology
  • Receptors, CXCR4 / physiology
  • Receptors, Interleukin-8B / physiology
  • Signal Transduction


  • CXCR4 protein, human
  • CXCR4 protein, mouse
  • Cell Adhesion Molecules
  • Receptors, CXCR4
  • Receptors, Interleukin-8B
  • Peptide Hydrolases