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. 2011;2011:203901.
doi: 10.1155/2011/203901. Epub 2011 Aug 18.

Adipokines and Osteoarthritis: Novel Molecules Involved in the Pathogenesis and Progression of Disease

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Free PMC article

Adipokines and Osteoarthritis: Novel Molecules Involved in the Pathogenesis and Progression of Disease

Javier Conde et al. Arthritis. .
Free PMC article

Abstract

Obesity has been considered a risk factor for osteoarthritis and it is usually accepted that obesity contributes to the development and progression of osteoarthritis by increasing mechanical load of the joints. Nevertheless, recent advances in the physiology of white adipose tissue evidenced that fat cells produce a plethora of factors, called adipokines, which have a critical role in the development of ostearthritis, besides to mechanical effects. In this paper, we review the role of adipokines and highlight the cellular and molecular mechanisms at play in osteoarthritis elicited by adipokines. We also emphasize how defining the role of adipokines has broadned our understanding of the diversity of factors involved in the genesis and progression of osteoarthritis in the hope of modifying it to prevent and treat diseases.

Figures

Figure 1
Figure 1
Schematic representation of the complex network that links white adipose tissue dysfunction, bone, and cartilage tissues. Dysfunctional fat produces an excess of proinflammatory adipokines that are able to interact with bone cells, synovial cells, and chondrocytes by inducing proinflammatory mediators (cytokines, ROS, NO) and cartilage degradative factors (metalloproteases and ADAMTSs).

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