Paracrine molecules of mesenchymal stem cells for hematopoietic stem cell niche

Bone Marrow Res. 2011;2011:353878. doi: 10.1155/2011/353878. Epub 2011 Sep 22.


Hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) are both adult stem cells residing in the bone marrow. MSCs interact with HSCs, they stimulate and enhance the proliferation of HSCs by secreting regulatory molecules and cytokines, providing a specialized microenvironment for controlling the process of hematopoiesis. In this paper we discuss how MSCs contribute to HSC niche, maintain the stemness and proliferation of HSCs, and support HSC transplantation.