piR-823, a novel non-coding small RNA, demonstrates in vitro and in vivo tumor suppressive activity in human gastric cancer cells

Cancer Lett. 2012 Feb 1;315(1):12-7. doi: 10.1016/j.canlet.2011.10.004. Epub 2011 Oct 10.

Abstract

Piwi-interacting RNAs (piRNAs), new non-coding small RNAs, are association with chromatin organization, messenger RNA stability and genome structure. However, the roles of piRNA in carcinogenesis are not clearly defined. By using real-time reverse transcription-polymerase chain reaction technology, we found that the expression level of piR-823 in gastric cancer tissues was significant lower than that in non-cancerous tissues. After increase the level of piR-823 in gastric cancer cells, cell growth was inhibited. The results of xenograft nude mice model confirmed its tumor suppressive properties. All of the evidences indicated that piR-823 play a crucial role in the occult of gastric cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Animals
  • Cell Growth Processes / genetics
  • Cell Line
  • Cell Line, Tumor
  • Down-Regulation
  • Female
  • Genes, Tumor Suppressor
  • Humans
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Middle Aged
  • RNA, Small Untranslated / administration & dosage*
  • RNA, Small Untranslated / biosynthesis*
  • RNA, Small Untranslated / genetics
  • Stomach Neoplasms / genetics*
  • Stomach Neoplasms / metabolism
  • Stomach Neoplasms / pathology
  • Stomach Neoplasms / therapy*
  • Transfection
  • Xenograft Model Antitumor Assays

Substances

  • RNA, Small Untranslated