Actin organization and dynamics in filamentous fungi

Nat Rev Microbiol. 2011 Nov 2;9(12):876-87. doi: 10.1038/nrmicro2666.


Growth and morphogenesis of filamentous fungi is underpinned by dynamic reorganization and polarization of the actin cytoskeleton. Actin has crucial roles in exocytosis, endocytosis, organelle movement and cytokinesis in fungi, and these processes are coupled to the production of distinct higher-order structures (actin patches, cables and rings) that generate forces or serve as tracks for intracellular transport. New approaches for imaging actin in living cells are revealing important similarities and differences in actin architecture and organization within the fungal kingdom, and have yielded key insights into cell polarity, tip growth and long-distance intracellular transport. In this Review, we discuss the contribution that recent live-cell imaging and mutational studies have made to our understanding of the dynamics and regulation of actin in filamentous fungi.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actin Cytoskeleton / genetics
  • Actin Cytoskeleton / physiology*
  • Actin Cytoskeleton / ultrastructure*
  • Actins / genetics
  • Actins / physiology*
  • Actins / ultrastructure
  • Biological Transport
  • Cell Polarity
  • Cytokinesis
  • Endocytosis
  • Exocytosis
  • Fungal Proteins / genetics
  • Fungal Proteins / physiology*
  • Fungal Proteins / ultrastructure
  • Fungi / genetics
  • Fungi / growth & development
  • Fungi / physiology*
  • Fungi / ultrastructure*
  • Gene Expression Regulation, Fungal
  • Hyphae / genetics
  • Hyphae / physiology
  • Hyphae / ultrastructure
  • Mutation
  • Organelles / metabolism


  • Actins
  • Fungal Proteins