Circulating anti-Mullerian hormone levels in adult men are under a strong genetic influence

J Clin Endocrinol Metab. 2012 Jan;97(1):E161-4. doi: 10.1210/jc.2011-1697. Epub 2011 Nov 2.

Abstract

Context: The determinants of serum anti-Müllerian hormone (AMH) levels in adult men remain unclear.

Objective: The objective of the study was to investigate the genetic and environmental components in determining postpubertal AMH levels in healthy men.

Design and participants: Serum AMH levels, body mass index (BMI), and fat mass (dual energy x-ray absorptiometry) were measured in 64 healthy male (23 monozygotic and 41 dizygotic) twin pairs.

Results: Postpubertal AMH levels were highly genetically determined (broad sense heritability 0.92, 95% confidence interval 0.83-0.96). AMH correlated negatively with BMI (r = -0.26, P = 0.030) and fat mass (r = -0.23, P = 0.048). As AMH, BMI had a high heritability (0.68, 95% confidence interval 0.39-0.83), but no genetic correlation was observed between them.

Conclusions: AMH levels in men after puberty are under a strong genetic influence. Twin modeling suggests that AMH and BMI are influenced by different sets of genes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Twin Study

MeSH terms

  • Absorptiometry, Photon
  • Adult
  • Anti-Mullerian Hormone / blood*
  • Anti-Mullerian Hormone / genetics
  • Body Composition
  • Body Mass Index
  • Environment*
  • Gene-Environment Interaction
  • Genes / physiology*
  • Humans
  • Male
  • Obesity / blood
  • Obesity / genetics
  • Overweight / blood
  • Overweight / genetics
  • Puberty / blood
  • Puberty / metabolism
  • Puberty / physiology
  • Twins
  • Young Adult

Substances

  • Anti-Mullerian Hormone