Flavivirus Cell Entry and Membrane Fusion

Viruses. 2011 Feb;3(2):160-71. doi: 10.3390/v3020160. Epub 2011 Feb 22.


Flaviviruses, such as dengue virus and West Nile virus, are enveloped viruses that infect cells through receptor-mediated endocytosis and fusion from within acidic endosomes. The cell entry process of flaviviruses is mediated by the viral E glycoprotein. This short review will address recent advances in the understanding of flavivirus cell entry with specific emphasis on the recent study of Zaitseva and coworkers, indicating that anionic lipids might play a crucial role in the fusion process of dengue virus [1].

Keywords: West Nile virus; anionic lipids; cell entry; dengue; flavivirus; membrane fusion; negatively charged lipids; receptor.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Membrane / metabolism
  • Cell Membrane / virology
  • Dengue / metabolism
  • Dengue / virology
  • Dengue Virus / metabolism*
  • Endocytosis
  • Endosomes / chemistry
  • Endosomes / metabolism
  • Endosomes / virology
  • Humans
  • Membrane Fusion
  • Membrane Lipids / metabolism*
  • Viral Envelope Proteins / metabolism
  • Virus Internalization*
  • West Nile Fever / metabolism
  • West Nile Fever / virology
  • West Nile virus / metabolism*


  • Membrane Lipids
  • Viral Envelope Proteins