General health, health-related quality of life and sexual health after pediatric liver transplantation: a nationwide study

Am J Transplant. 2012 Feb;12(2):420-7. doi: 10.1111/j.1600-6143.2011.03819.x. Epub 2011 Nov 2.


The long-term impact of pediatric liver transplantation (LT) and its complications on general health, health-related quality of life (HRQoL) and sexual health were assessed. We conducted a national cross-sectional study of all pediatric recipients who underwent LT between 1987 and 2007. Of 66 survivors, 57 participants (86%) were compared to randomly chosen healthy controls (n = 141) at 10.7 ± 6.6 years posttransplant. PedsQL4.0, SF-36, DISF-SR and AUDIT questionnaires for appropriate age groups were used. Patients and controls <7 years had similar HRQoL and 54% of patients aged over 7 scored within the controls' normal range on all HRQoL domains. In adult survivors, physical functioning and general health were decreased (p < 0.05). Biliary complications, reoperations and obesity were independently associated with reduced HRQoL (p < 0.05 for all). Still 64% of adult survivors considered their health excellent. Sexual health was similar to controls but LT recipients may experience problems with their orgasm strength (p = 0.050) and condom-based contraception was more common after LT than among controls (58% and 12%, p < 0.001). In conclusion, normal HRQoL and sexual health are achievable post-LT.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Cross-Sectional Studies
  • Female
  • Finland
  • Follow-Up Studies
  • Health Status*
  • Humans
  • Liver Transplantation / psychology*
  • Male
  • Quality of Life*
  • Registries*
  • Retrospective Studies
  • Sexual Behavior / physiology*
  • Time Factors
  • Treatment Outcome
  • Young Adult