Long term outcomes in patients with preoperative generalized interictal epileptiform abnormalities following amygdalohippocampectomy

Epilepsy Res. 2012 Mar;99(1-2):171-5. doi: 10.1016/j.eplepsyres.2011.10.007. Epub 2011 Nov 1.


We evaluated long term surgical outcomes in 21 patients with temporal lobe epilepsy and presurgical generalized interictal epileptiform discharges (IEDs). Following amygdalohippocampectomy, 12 patients (57.1%) were noted to have favorable outcomes (Engel classification of I-II). Favorable outcomes were significantly associated with a history of auras prior to seizure onset (p=0.021), the absence of generalized IEDs on postoperative EEG (p=0.024), and the presence of focal slowing on postoperative EEG (p=0.045).

MeSH terms

  • Adolescent
  • Adult
  • Amygdala / surgery*
  • Child
  • Electroencephalography* / methods
  • Epilepsy, Temporal Lobe / physiopathology*
  • Epilepsy, Temporal Lobe / surgery*
  • Female
  • Hippocampus / surgery*
  • Humans
  • Male
  • Middle Aged
  • Postoperative Period
  • Preoperative Care* / methods
  • Retrospective Studies
  • Treatment Outcome
  • Young Adult