Activity of pegylated liposomal doxorubicin for extragenital mullerian adenosarcoma with sarcomatous overgrowth: a case report and a review of the literature

Eur J Gynaecol Oncol. 2011;32(5):542-6.

Abstract

A 47-year-old woman was diagnosed with extragenital mullerian adenosarcoma with sarcomatous overgrowth. One month after her initial surgery, the patient developed pelvic recurrence, which was completely excised by surgery. However, one month later, the patient developed further recurrences in her pelvis and upper abdomen. A clinical complete response was achieved with three cycles of liposomal doxorubicin and is currently clinically free of disease. So far, including the present case, 23 cases of extragenital mulleian adenosarcoma have been reported in the English literature. Because of the rarity of the reported cases, there are no treatment guidelines based on a good level of evidence. In the current report, through a literature review, we provide information on the activity of pegylated liposomal doxorubicin for extragenital mullerian adenosarcoma with sarcomatous overgrowth.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Abdominal Neoplasms / drug therapy*
  • Abdominal Neoplasms / pathology
  • Adenosarcoma / drug therapy*
  • Adenosarcoma / pathology
  • Doxorubicin / analogs & derivatives*
  • Doxorubicin / therapeutic use
  • Female
  • Humans
  • Middle Aged
  • Mixed Tumor, Mesodermal / drug therapy*
  • Mixed Tumor, Mesodermal / pathology
  • Pelvic Neoplasms / drug therapy*
  • Pelvic Neoplasms / pathology
  • Polyethylene Glycols / therapeutic use*
  • Sarcoma / pathology

Substances

  • liposomal doxorubicin
  • Polyethylene Glycols
  • Doxorubicin