Biologics and infections: lessons from tumor necrosis factor blocking agents

Infect Dis Clin North Am. 2011 Dec;25(4):895-910. doi: 10.1016/j.idc.2011.08.002.

Abstract

In the decade since tumor necrosis factor α (TNF-α) antagonists were first approved for clinical use, they have proven invaluable for the treatment of specific types of chronic inflammation. Currently licensed TNF blockers fall into two classes, monoclonal antibody (or antibody fragments) and soluble receptor. Although they are equally effective in rheumatoid arthritis and psoriasis, important differences have emerged with regard to efficacy in granulomatous inflammation and risks of granulomatous infections, particularly tuberculosis. This article focuses on recent studies that inform prevention and management of infections in this susceptible patient population.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents / adverse effects*
  • Anti-Inflammatory Agents / therapeutic use
  • Antibodies, Monoclonal / adverse effects*
  • Antibodies, Monoclonal / therapeutic use
  • Bacterial Infections / etiology*
  • Humans
  • Immunologic Factors / adverse effects*
  • Immunologic Factors / therapeutic use
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors*
  • Virus Diseases / etiology*

Substances

  • Anti-Inflammatory Agents
  • Antibodies, Monoclonal
  • Immunologic Factors
  • Tumor Necrosis Factor-alpha