Gene therapy for lung neoplasms

Clin Chest Med. 2011 Dec;32(4):865-85. doi: 10.1016/j.ccm.2011.08.006. Epub 2011 Oct 7.


Both advanced-stage lung cancer and malignant pleural mesothelioma are associated with a poor prognosis. Advances in treatment regimens for both diseases have had only a modest effect on their progressive course. Gene therapy for thoracic malignancies represents a novel therapeutic approach and has been evaluated in several clinical trials. Strategies have included induction of apoptosis, tumor suppressor gene replacement, suicide gene expression, cytokine-based therapy, various vaccination approaches, and adoptive transfer of modified immune cells. This review considers the clinical results, limitations, and future directions of gene therapy trials for thoracic malignancies.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Gene Expression Regulation, Neoplastic
  • Genetic Therapy / methods*
  • Genetic Vectors
  • Humans
  • Immunotherapy / methods
  • Lung Neoplasms / genetics
  • Lung Neoplasms / immunology
  • Lung Neoplasms / therapy*
  • Mesothelioma / genetics
  • Mesothelioma / immunology
  • Mesothelioma / therapy*